Multiple Sclerosis

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  • Created by: Paul
  • Created on: 07-12-12 11:55
Epidemiology - MS
20-40, mean AOO - 29, Affects USA, Europe, Australia (latitude dependent), Woman 2:1.
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Aetiology MS (1) - GENE Factors
HLA-DR15, inherited (7 x increase), APL - mediate autoimmune deviation and prevent encephalomyelitis
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Aetiology - MS (2) - Geographical
Solar flux, equatorial dependent, Ancestry (Anglo-Celtic 70%), Pre 15 affect
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Aetiology - MS (3) - Viral
Activating otherwise dormant T-cells (possibly similar epitopes) - could possibly explain the periodic bouts, Molecular Mimicary
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Aetiology - MS (4) - Nutrition
EFA, risk factors
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Rx - MS
IMT and therapy to relieve or modify symptoms, IMT is used to reduce frequency of relapses and to slow progression, PLG calfornia, Multidisciplinary approach
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Clinical Manifestations MS - Cerebral (Central) - Dependant on area affected with plaques
Cognitive dysfunction (attention, memory, visual perception, dysarthria, dysphasia), Fatigue, Pain, Depression, Euphoria, Seizures, Sensory loss, Spinal cord (cramps secondary to spasticity)
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Clinical Manifestations - MS - Visual - Dependant on area affected with plaques
Optic neuritis, Diplopia, Nystagmus
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Clinical Manifestations - MS - MSK - Dependant on area affected
Weakness, Spasms, Spasicity, Ataxia
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Clinical Manifestations - MS - Others - Dependant on area affected
Paraesthesias, Hypoesthesias, Unstable mood, Bowel, Urinary
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Other cards in this set

Card 2

Front

Aetiology MS (1) - GENE Factors

Back

HLA-DR15, inherited (7 x increase), APL - mediate autoimmune deviation and prevent encephalomyelitis

Card 3

Front

Aetiology - MS (2) - Geographical

Back

Preview of the front of card 3

Card 4

Front

Aetiology - MS (3) - Viral

Back

Preview of the front of card 4

Card 5

Front

Aetiology - MS (4) - Nutrition

Back

Preview of the front of card 5
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