Occurs activation of myelin reactive T-cells which express adhesion molecules. These allow entry into the BBB, These are activated following antigen presentation by cells such as macrophages and microglia.
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Multiple Sclerosis - Pathophysiology (1) - Part 2
Perivascular T-cells secrete inflammatory agents. Antibodies against myelin may be generated in the periphery or intrathecally. The ongoing inflammation leads to epitope spread and further secretion of inflammatory agents.
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Multiple Sclerosis - Pathophysiology (1) - Part 3
Activated microglia may release free radicals, nitric oxide and proteases which may cause further tissue damage
An unidentified factor results in oligodendrocyte apoptosis and direct or secondary microglia activation. T-cells re-enter the CNS and are activated by antigen presenting cells possibly in the Virchow-Robin spaces.
Amplification of the inflammatory process ensues, by as yet unidentified immune populations. Some microglia differentiate into macrophages which phagotose apoptotic oligodendrocytes
The degenerating myelin which may express phagocytic ligands on their abluminal surface. This paradigm shift makes no assumptions about the T-cell specificity or the auto-antigens involved or the epitopes from an unknown factor which lead to apopto
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Other cards in this set
Card 2
Front
Perivascular T-cells secrete inflammatory agents. Antibodies against myelin may be generated in the periphery or intrathecally. The ongoing inflammation leads to epitope spread and further secretion of inflammatory agents.
Back
Multiple Sclerosis - Pathophysiology (1) - Part 2
Card 3
Front
Activated microglia may release free radicals, nitric oxide and proteases which may cause further tissue damage
Back
Card 4
Front
An unidentified factor results in oligodendrocyte apoptosis and direct or secondary microglia activation. T-cells re-enter the CNS and are activated by antigen presenting cells possibly in the Virchow-Robin spaces.
Back
Card 5
Front
Amplification of the inflammatory process ensues, by as yet unidentified immune populations. Some microglia differentiate into macrophages which phagotose apoptotic oligodendrocytes
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