Pharmacology lecture 8

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What is the study of pharmacogenomics?
The association between GENOTYPE and RESPONSE to EXOGENOUS compounds
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What are differences in drug metabolism and transport caused by?
Genetic polymorphisms - SNP
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How does a decrease in liver function affect PK?
Decreases HEPATIC CLEARANCE and therefore TOTAL CL. Also and INCREASE in AUC and an INCREASE in HALF-LIFE. Doses of drugs adjusted on CHILD-PUGH SCORE
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The amount of .......... ............ will affect drug distribution
Adipose tissue
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How does age affect PK?
1) Maturation of hepatic CYPs 2) Maturation of intestinal CYP3A
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What is compartmental analysis based on?
Tissues lumped together. How fast their concentrations reach equilibrium with blood concentration
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What is physiology-based (PBPK) analysis?
When each major organ/tissue of the body has its own compartment
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Card 2

Front

What are differences in drug metabolism and transport caused by?

Back

Genetic polymorphisms - SNP

Card 3

Front

How does a decrease in liver function affect PK?

Back

Preview of the front of card 3

Card 4

Front

The amount of .......... ............ will affect drug distribution

Back

Preview of the front of card 4

Card 5

Front

How does age affect PK?

Back

Preview of the front of card 5
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