drug toxicology

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  • Created by: anna888
  • Created on: 02-02-23 12:16
define toxicology
study of adverse of chemicals on living systmes
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define adverse drug reactions
undesired effect of a drug in humans used in prophylaxis, diagnosi and therapy
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what are type a reactions
augmented. same pharmacological mechanism as drug or by increase in therapuetic effect. directly dose related. intrvention via dose reduction or use of antagonist in severe cases
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what are type b reactions
induced by immunological reactions(allergy) or genetic preispotion (idosyncratic) . not dose related. allergy requires previous exposition and occurs when drug metabolies interact with immune cell receptors. idosyncratic occurs without pre exposition, unp
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what are type c reactions
chronic use. direclty realted to cummalative dose. usually occurs after long term use. damage largely irreversible
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what are type d reactions
delayed. mainfest with significant delay. teratogenesis and mutagecity/carcinogenity. teratogenisis causes malformations and deformations to foetus and drug penetrates placenta barrier. mutations occur by a sudden chnage to genome. carcinogencity occurs w
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what are type e reaction
end of use. comes from withdrawal and rebound phenonoms. prevention by slow reduction in dose or avoid use of drug
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describe preclinical toxiocology regulations
test max does on rats. checks for hERG chanel binding (causes fatal arythmia). failure means recall from market. balance or risk vs ebenfits. risks vs hazard. snps can effect recations to drugs-indivudal
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define adverse drug reactions

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undesired effect of a drug in humans used in prophylaxis, diagnosi and therapy

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what are type a reactions

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what are type b reactions

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what are type c reactions

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