NSAIDs

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  • Created by: Popstar
  • Created on: 09-01-14 10:23
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  • NSAIDs
    • MOA
      • inhibits COX
        • Prevents production of prostanoids from Arachidonic acid
        • Subtypes of Cyclo-oxygenase
          • COX-1
            • homeostatic control of prostaglandins
            • Present in Most Cells
            • COX-2
              • Expression in inflammatory response
              • COXIBS - selective COX-2 inhibitors
                • Celecoxib & Etericoxib
                • Rofecoxib - withdrawn for serious ADRs
                • Adverse Effects
                  • Less GI effects than traditional NSAIDs
                  • CV effects
                    • reduced production of prostaglandin I2 which normally protects against atherosclerosis
                      • CV Effects
                        • Increased bleeding due to inhibition of platelet aggregation
          • COX-2
            • Expression in inflammatory response
            • COXIBS - selective COX-2 inhibitors
              • Celecoxib & Etericoxib
              • Rofecoxib - withdrawn for serious ADRs
              • Adverse Effects
                • Less GI effects than traditional NSAIDs
                • CV effects
                  • reduced production of prostaglandin I2 which normally protects against atherosclerosis
                    • CV Effects
                      • Increased bleeding due to inhibition of platelet aggregation
          • COX-3/1b
            • Brain & Spinal Chord
            • Pain perception
    • Pharmacological Actions
      • Analgesic effect
      • Antipyretic  effect
      • Anti-inflammatory effect
        • Strong
          • Ketoprofen
          • Piroxicam
        • Moderate
          • Ibuprofen
          • Naproxen
    • Clinical Uses
      • Rheumatoid arthritis
      • Oesteoathritis
      • Other anthropathies
      • Acute Gout
      • Inflammation pain and tissue injury
      • Fever
    • Adverse Effects
      • GI effects
        • ulcers
          • NSAIDs contraindicated in ulcer patients
        • nausea, vomiting, dyspepsia, abdominal pain
        • minimised by co-admin of PPI e.g. omeprazole
      • Hypersensitivity Reactions
      • Renal Effects
    • ASPIRIN
      • Salicylate
      • 166x more potent at COX1 than COX2
      • Therapeutic Effects
        • Peripheral& Central effects
        • Anti-thrombotic
        • Anti-cancer (colon)
        • Alzheimer's
        • Radiation-induced Diarrhoea
        • Analgesic
        • Antipyretic
        • Anti-inflammatory
      • Adverse Effects
        • Gestric irritation & haemorrhage
        • CNS
        • asthma
        • Reye's syndrome
        • Toxic - metabolic acidosis

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