Microbiology lecture 9

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What is the secretion in the assembly of a fibril pilus?
Via the Sec machine
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What is the chaperone in the assembly of a fibril pilus?
Periplasmic space
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What is the usher in the assembly of a fibril pilus?
outer membrane
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What is the pilus in the assembly of a fibril pilus?
fimbrillin/FimA
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What is the adhesion in the assembly of a fibril pilus?
FimH - lectin like proteins bind sugars
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What are the two methods of protein secretion?
Unfolded (polypeptides), folded (proteins)
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What method is unfolded protein secretion?
SEC - majority of secretion pathways, facilitate insertion of proteins into inner membrane
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What method is folded protein secretion?
TAT
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How is protein secretion achieved in Gram -ve bacteria?
Inner membrane --> SEC, Outer membrane --> specific system eg. fimbriae
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Pathogenicity =
Qualitative
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Virulence =
Quantitative
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What are exotoxins encoded on?
Plasmid or bacteriophage genomes
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What do cytolytic exotoxins do?
Lead to cell lysis
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What do AB exotoxins do?
B binds specific cell receptors --> B facilitates uptake of A --> A inhibits cellular process or damages cell
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What do superantigens do?
Over stimulate the immune system
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What do enterotoxins do?
Specific group that acts on small intestine
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What do neurotoxins do?
Often AB toxins that target nerve cells
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What is toxicity?
The ability to cause damage by means of a performed toxin. Infect 1 site and then damage another by releasing toxin
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What is immunogenicity?
Ability to provoke an immune response
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Card 2

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What is the chaperone in the assembly of a fibril pilus?

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Periplasmic space

Card 3

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What is the usher in the assembly of a fibril pilus?

Back

Preview of the front of card 3

Card 4

Front

What is the pilus in the assembly of a fibril pilus?

Back

Preview of the front of card 4

Card 5

Front

What is the adhesion in the assembly of a fibril pilus?

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