Autoimmune Disease 3.0 / 5 based on 1 rating ? BiologyUniversityOCR Created by: RuthCreated on: 06-02-13 10:34 What percentage of people does a pathogenic response occur due to autoimmunity? 5% 1 of 19 What constitutes an autoimmune disease? High titre of reactive antibodies and lymphocytes. THere must be a beneficial effect of immune suppressive intervention 2 of 19 What are the main two types of autoimmune disease? Organ specific disease, non Organ specific disease 3 of 19 What hypersensitivity is ascociated with organ specific? Type II, IV and V hypersensitivity 4 of 19 What hypersensitivity is ascociated with non organ specific? Type III 5 of 19 Name some autoimmune diseases? Graves, type I diabetes, Hashimotos, pernicious anaemia, SLE 6 of 19 What is graves? Antibody against stimulatory TSH receptor 7 of 19 So is Graves organ specific? Yes 8 of 19 Rheumatoid arthritis Antibodies against citrullinated proteins 9 of 19 Is rheumatoid arthritis organ specific? No 10 of 19 Hashimotos disease Autoantibodies against thyroid peroxidase 11 of 19 Is Hashimotos organ specific? Yes 12 of 19 SLE Systemic Lupus Erythematosus has antibodies against dsDNA, SSA and SSB histones 13 of 19 So SLE is organ specific? NO 14 of 19 What factors influence development of autoimmune disease? Genetic factors, female, infection, diet, life event 15 of 19 What specific genetic factors in autoimmune disease? MHC molecules 16 of 19 What is it specifically about being female? Oestrogen, severity is affected during pregnancy 17 of 19 How can infection trigger autoimmune disease? Cross reactive agents, abberent expression of MHC class II, polyclonal activation, defective Treg cells 18 of 19 How can you treat autoimmune disease? Antiinflamatory drugs, immunosupression drugs, blocking the action of TNF, HRT in some cases. 19 of 19
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