Cell Junctions

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  • Created by: Sarah
  • Created on: 03-05-17 09:25
what do hemidesmosomes do?
anchor intermediate filaments to the basal lamina
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what signals open up/control gap junctions?
Calicum ions, PH and signals
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what is pemphigus?
autoimmune skin blistering disease
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what is pemphigus caused by?
body attacks desmoglein affects adheren junctions
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what are adheren junctions made up of?
cadherin (E type)
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if adherens are heterophilic what do they depend on?
calcium ions
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if adherens are homophillic what do they have?
a homophillic reaction
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where are desmisomes present?
in epithelia
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what are desmisomes for?
joins intermediate filaments in one cell to those in neighbouring cell
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what are main functions of junctions?
integrity, communication, cytoskeleton role, compartments, protein families, dynamic
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what are hemidesmosomes made of?
integrins and intermediate filaments
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what are adherens junctions also known as?
belt desmosomes/adhesion belt
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what do adheren junctions do?
join an actin bundle in one cell to an actin bundle in a neighbouring cell
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how does an adhesion belt/belt desmosome work?
contractile mechanism, actin based movement
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an example of belt desmosome working?
formation of neural tube
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what are the roles of tight junctions?
forms a barrier (no leak), prevent fluid, ion M flow, paracellular transport
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what are other names for tight junctions?
zonae occludens or occluding junctions
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what is the experiment used for tight junctions?
applying electrons to the apical membrane
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what is the difference when applying electron dense material to the outside and inside of tight junctions?
outside- doesn't come inside, inside- goes no further that tight junction
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where are tight junctions found?
in the epithelia of the gut
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tight junctions separate membrane proteins what proteins on the apical surface?
glycolipids cholesterol
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tight junctions separate what on the basolateral surface?
phosphatidylcholine
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how big is the gap in a gap junction?
2-4um
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what do gap junctions allow?
cell cell communications is like a little hollow tunnel to transport stuff
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where are gap junctions found?
heart, smooth muscle and neurons
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what do gap junctions allow through?
ip3, ATP, cAMP, amino acids and ions
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what do gap junctions prevent going through?
proteins
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influx of calcium ions does what to gap junctions?
potentially shuts to limit damage to cells
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order of formation of gap junctions?
connexins/innexins -> connexons --> intracellular channel
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are connexons homomeric or hetromeric?
can be either
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Card 2

Front

what signals open up/control gap junctions?

Back

Calicum ions, PH and signals

Card 3

Front

what is pemphigus?

Back

Preview of the front of card 3

Card 4

Front

what is pemphigus caused by?

Back

Preview of the front of card 4

Card 5

Front

what are adheren junctions made up of?

Back

Preview of the front of card 5
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