phosphatidyl serine flips to outside membrane. so it can be labelled annexin V. so can bind to phagocytes. binding stimulates release of anti-inflammatory cytotoxins.
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3rd stage
Apoptotic cells lose electrochemical gradient across cell membranes of inner membrane on mitochondria. Can be measured using +ve charged fluroescent dyes.
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What are capases
4 genes that are constantly expressed but but silenced. Capases target: =DNA cleavage =lamins(nuclear scaffold) =Gelsolin cleavage membrane blebbing. they bind with cyestine at active site and bind to aspartate sites.
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Intrinsic apoptosis
causes mitochondria membranes to leak cytochrome c and activate capases in cytoplasm. Due to DNA damage / cytotoxic drugs that have entered the cell.
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Glutamate synthesis
Nerve terminals/glial cells reuptake released glutamate. convert it to glutamine. which is then transported to nerve terminal and back to glutamate to be put into vesicles.
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Other cards in this set
Card 2
Front
2nd stage
Back
phosphatidyl serine flips to outside membrane. so it can be labelled annexin V. so can bind to phagocytes. binding stimulates release of anti-inflammatory cytotoxins.
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