Apoptosis and Necrosis

HideShow resource information
what is the first stage of apoptosis
DNA cleaved by endonuclease in a ladder pattern.
1 of 6
2nd stage
phosphatidyl serine flips to outside membrane. so it can be labelled annexin V. so can bind to phagocytes. binding stimulates release of anti-inflammatory cytotoxins.
2 of 6
3rd stage
Apoptotic cells lose electrochemical gradient across cell membranes of inner membrane on mitochondria. Can be measured using +ve charged fluroescent dyes.
3 of 6
What are capases
4 genes that are constantly expressed but but silenced. Capases target: =DNA cleavage =lamins(nuclear scaffold) =Gelsolin cleavage membrane blebbing. they bind with cyestine at active site and bind to aspartate sites.
4 of 6
Intrinsic apoptosis
causes mitochondria membranes to leak cytochrome c and activate capases in cytoplasm. Due to DNA damage / cytotoxic drugs that have entered the cell.
5 of 6
Glutamate synthesis
Nerve terminals/glial cells reuptake released glutamate. convert it to glutamine. which is then transported to nerve terminal and back to glutamate to be put into vesicles.
6 of 6

Other cards in this set

Card 2

Front

2nd stage

Back

phosphatidyl serine flips to outside membrane. so it can be labelled annexin V. so can bind to phagocytes. binding stimulates release of anti-inflammatory cytotoxins.

Card 3

Front

3rd stage

Back

Preview of the front of card 3

Card 4

Front

What are capases

Back

Preview of the front of card 4

Card 5

Front

Intrinsic apoptosis

Back

Preview of the front of card 5
View more cards

Comments

No comments have yet been made

Similar Chemistry resources:

See all Chemistry resources »See all Cell biology and neuroscience resources »