LD50/ED50 or TD50/ED50 The larger the number the greater the safety of the drug., however doesn;t show overlap. eg high efficacy dose may mean small toxicity.
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How can altering a drug effect toxicity?
ADME- absorption, distribution, metabolism and excretion
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Effects of paracetamol
metabolised-combination with sulfate and glucuronic acid/oxidation and glutathionine.
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Overdose of paracetamol
depletion of glutathionine, reacts with liver proteins hepatic necrosis and death
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Metabolism of aspirin
metabolised by esterases to salicylic acid then conjugated with glucuronic acid/glycine. Salicylate interferes with function of ETC in mitochondria.-hyperventilation etc- metabolic acidosis can be fatal
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What is clinical toxicology
diagnosis, treatment and prevention of poisioning.
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Forensic toxicology
Arsenic, mercury, cyanide to kill people
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Industrial/occupation toxicology
mining etc
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Environmental toxicology
tobacco smoking, lead etc
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Ecotoxicology
non-human species eg oil spills
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Genetic toxicology
mutagenic (gene mutations) etc
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Regulatory toxicology
How safe it is. testing by giving to animals etc.
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Other cards in this set
Card 2
Front
How can altering a drug effect toxicity?
Back
ADME- absorption, distribution, metabolism and excretion
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