Immunology
- Created by: jo bill
- Created on: 23-12-14 12:24
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defence against disease
- usually microorganisms
- for them, the body is their ideal house
- adult gut -> 500 microbal species - COMMENSAL ORGANISMS
- we have eveolved with these and we need them as they protect against infection
- competion for space
- production of anti-bacterials -COLICIN
- antibiotics are bad because they destroy our commensals
PATHOGENS
- BACTERIAL
- VIRUSES
- FUNGI
- PARASITES
we have a multilayer defebce system, this is made up of mechanical, chemical and microbiological barriers
if these barriers are breached
- INNATE IMMUNITY comes into play
- the innate immune system
- reacts quickly
- recognises pathogen
- destroys the invaders
- induces the INFLAMMATORY RESPONSE
- informs ADAPTIVE IMMUNITY
pathogens are recognised and destroyed
- bacterial cell surface induces cleavage and activation of complement
- one complement fragment covalently bond to the bacterium, the other attracts an effector cell
- the complement receptor on the effector cell binds to the complememnt fragment on the bacterium
- the effector cell engulfs the bacterium, kills it and breaks it down
inflammatory response
- healthy skin is not inflammed
- surface wound induces bacteria, which activate resident effector cells to secrete cytokines
- vasodilation and increased vascular permeability allow fluid, protein, and inflammatory cells to leave blood and enter tissue
- the infected tisusue becomes inflammed, causing redness, heat, swelling and pain
adaptive immunity
- innate immunity can LIMIT infection but it needs some help to REDUCE infection
- adaptive immunity is
- provided by lymphocytes
- adapts to pathogens
- long lasting
effector mechanisms in adaptive immunity
- progenitor cells give rise to lymphocytes with different specifity
- detection of a foreign antigen by the specific lymphocytes - CLONAL SELECTION
- activation results in proliferation and differentiation to many effector cells specific for the infection - CLONAL EXPANSION
- infection termination
immproves well with age
- PRIMARY IMMUNE RESPONSE- first encounter with a pathogen
- longer lag time
- less specific response
- SECONDARY IMMUNE RESPONSE - second and subsequent infections with the same pathogen
- faster response
- more specific response
- principle of vaccination
all immune sytem cells derive from haematopoeitic stem cells
- haematopoiesis id formation of blood cells- red and white
- white blood cells- leukyocytes- immune system cells
- haematopoeisis shifts during development - yolk sac, liver spleen, bone marrow
- haematopoiesis occurs throughout…
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