no gi enzyme degrade, suitable for patient who cant swallow
3 of 16
disadvantages of rectal route
poor compliance, doesnt avoid gi entirely as if absorbed through superior rectal vein it has 1st pass, difficult manufaturing
4 of 16
physiological factors effecting absorbtion
rectal fluid(dissolution), rectal mucas-pH 7-8, contents- enema, motility of rectum
5 of 16
what are two dosage forms
semi solids (creams solids and bases) and suppositories
6 of 16
describe semi solids
topical admin, local effect, applicator
7 of 16
describe suppositories, base , release mechanism
single dose, lipophillic- water soluble base- glycerol gelatin. hydrophillic- gylceride fatty acid base. base should melt at 37. melting>sedimentation>wetting>dissolution
8 of 16
suppository excipents
surface active agents (enhance wetting properties), hygroscopity reducing agents ( protection in packaging), melting point controllin agents (37)
9 of 16
vaginal anatomy
mucas wall pH 4-5, high SA, highly vascular
10 of 16
postives of vaginal route
local effect so smaller dose, prolonged release, no gi no 1st pass
volume, visosity and pH of mucus, stage of menstral cycle, sex, age
14 of 16
state the dosage forms
semi solids-creams gels ointments applicators required. tablets- lactose filler- applicators. supositories- glycerol gelatin base, buffered to pH 4-5. vaginal rings- implants- drug released over time
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