LPS and TLR4

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  • LPS found on bacteria
    • TLR4 recognises LPS
      • Complex of TLR4, LPS, MD2 and CD14
        • MyD88 binds TLR4
          • Activates IRAK4
            • Phosphorylates TRAF6
              • Activates and phosphorylates IKK
                • Causes signalling cascade with conformational changes to the cell
                  • IKK Phosphorylates IkB
                    • IkB is degraded and NFkB is released
                      • NFkB enters nucleus and activates transcription of inflammatory cytokines which re synthesised in the cytoplasm and secreted via the ER

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