LPS and TLR4
- Created by: Martha Brown
- Created on: 16-05-15 01:40
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- LPS found on bacteria
- TLR4 recognises LPS
- Complex of TLR4, LPS, MD2 and CD14
- MyD88 binds TLR4
- Activates IRAK4
- Phosphorylates TRAF6
- Activates and phosphorylates IKK
- Causes signalling cascade with conformational changes to the cell
- IKK Phosphorylates IkB
- IkB is degraded and NFkB is released
- NFkB enters nucleus and activates transcription of inflammatory cytokines which re synthesised in the cytoplasm and secreted via the ER
- IkB is degraded and NFkB is released
- IKK Phosphorylates IkB
- Causes signalling cascade with conformational changes to the cell
- Activates and phosphorylates IKK
- Phosphorylates TRAF6
- Activates IRAK4
- MyD88 binds TLR4
- Complex of TLR4, LPS, MD2 and CD14
- TLR4 recognises LPS
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