Phagosomal PAMP or DAMP
- Created by: Martha Brown
- Created on: 16-05-15 02:33
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- Phagosomal PAMP or DAMP
- NLR activated
- Does not activate gene expression
- Forms an enzyme that activates cytokines
- Activate the incorporation of the complex with pro-caspase-1
- Cleaves into pro-IL-1beta and pro-IL-18
- Becomes bioactive IL-1beta and IL-18
- IL-1 goes into the brain and cause fever. It is very important for protecting against infection
- IL-18 causes NK cells and T cells to release IFN-gamma
- Becomes bioactive IL-1beta and IL-18
- Cleaves into pro-IL-1beta and pro-IL-18
- Activate the incorporation of the complex with pro-caspase-1
- NLR associates with ASC (an adaptor molecule)
- Complex binds caspase-1 to form a tertiary structure
- Forms a heptamer. Caspase-1 activated at this point
- Complex binds caspase-1 to form a tertiary structure
- NLP-P1 is good to respond to toxins
- NLRB3 can respond to disruption of cell function and cell membrane damage which detects potassium leakage
- NLR activated
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