occular route of administration 0.0 / 5 ? BiotechnologyoccularUniversityNone Created by: anna888Created on: 14-03-23 15:09 describe cornea set up sensory nerves, covered by tears produced by lacrima gland 1 of 11 describe lacrima gland outer lipid layer, central aqueus, inner mucas. tears pH around 7 2 of 11 describe 3 main routes of delivery cornea- topical to aqueous humour. pericocular- by passes cornea epithelium. intraviteral- dieryly into viterous humour 3 of 11 describe the barriers to topical corneal delivery tear and blinking as fluid clearance. mas does of 20-30 miro litres 4 of 11 describe 4 formulation considerations for topical route 1. pH - best around 3-9. 2,. viscoity- increases residence time 3.sterility-prevents infections 4. tonicity- isotonic to prevent dehydration or oedema 5 of 11 solution as preparation majority prerp, usually in eye drops 6 of 11 ointment as preparation reduce clearance , used for poorley water soluble drugs 7 of 11 gels as preparation semi solid with water soluble base 8 of 11 ion exchange resin as prepartaion insoulble ion exhange complexes form bewteen drug ionically bonded to resin. release via interactions with tears 9 of 11 describe occular implants controlled drug delivery systems into viterous. bio or non biodegradable polymers 10 of 11 describe intraviteral injections injcetion of drug solution of suspenstion into viterous cavity, 20-100 microliters, main drug entery route to posterior eye section 11 of 11
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