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  • Viral infection
    • TLR3 is stimulated
      • TLR3 stimulates and activates IRF3
        • IRF3 leads to the induction of IFN
          • Leads to Type I response (IFN-alpha and IFN-beta)
            • Causes ISGs (interferon stimulated genes) to be transcribed
              • Interferes with viral replication and inhibits viral protein synthesis
                • More important than IL-6
                  • Cell dies as ISGs stop viral proteins being produced so it turnoff self protein production too
    • Produces IFN
      • Increases the alertness of the immune system by increasing costimulatorymolecule expression
      • Adaptive responses won't follow if the cell dies here


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