avoids 1st pass so lower dose, low enzyme acivity, can be direct route to brain
2 of 13
describe anatomical fature of nasal route, where are drugs absorbed
mucousal membrane with goblet cells to secrete mucas. drug abs acros turbinates and septum
3 of 13
lipo vs hydrophillic drug transport
lipo= transcellulary via passive diffusion. hydro= paracellulary via tight junctions
4 of 13
how to drugs get from nasal route-brain
across olfactory mucosa into cns, by pass blood brain barrier
5 of 13
describe clearnace of particles in nasal route
small drugs attach to mucas on epithelium, cillia sweep the mucas toward pharynx-mucocillary clearnace which ocurs every 12-15 mins. larger particles trapped by nasal filter
6 of 13
factors effecting systemic abs?
solubility, hydro/lipophillicy(lipo transcellular has higher bioavilability), degree of ionisaton(unionised better), nassal epithelium permability, muscosal contact time, enzyme activity, molecule size
7 of 13
describe the three nasal devices
1. dropper plastic bottle- cheap and simple. requires skill and dexterity for even application. volume admin subject to patients- drug must have large theraputic window 2. nasal spray- pre filled syringe, exact dose. 3. nasal tube- semi solids, messy and
8 of 13
nature of aural route
local
9 of 13
describe ear drops
topical, solution or suspesion in vechile
10 of 13
describe ear wax
mainly lipophillic, protecive film of meatal skin-only removed if issue
11 of 13
roles of cerumenolytics
to soften ear wax to allow its removal
12 of 13
what is otitis externa
inflammtion of meatal skin
13 of 13
Other cards in this set
Card 2
Front
postives of nasal
Back
avoids 1st pass so lower dose, low enzyme acivity, can be direct route to brain
Card 3
Front
describe anatomical fature of nasal route, where are drugs absorbed
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