Receptors 0.0 / 5 ? BiologyPharmacologyUniversityNone Created by: Annabel ForsdykeCreated on: 18-05-15 13:50 Three cellular locations of receptors Nuclear receptors, intracellula receptors, plasma membrane receptors. 1 of 19 Example of nuclear receptors oestrogen receptor, retinoic acid receptors. Zinc fingers 2 of 19 Example of intracellular membrane receptors Ryanodine receptor, iP3 receptor 3 of 19 The three superfamiles of plasma membrane receptors Ligand gated ion channels, GPCRs, intrinsic enzyme receptor superfamily 4 of 19 The three subclasses of ligand gated ion channels Nicotinic R like, ATP R, Ionotropic glutamate R 5 of 19 Examples of nicotinic R like and the structure nAChR, 5-HT3, GABAa, Glycine, ZAC. They have 5 subunits, each with 4 transmembrane domains. 6 of 19 Examples of ATP R's P2X - there are 7 subtypes. They have three subunits each with two transmembrane domains. 7 of 19 Examples of ionotropic glutamate receptors NMDA, AMPA, Kainate. they have 4 subunits, and the subunit has three TMD and a P loop between TMD 1 and 2 8 of 19 Which types are inhibitory and what do they let through? GabaA, Glycine, Cl-. 9 of 19 The three families of GPCRs Rhodopsin-like, metabotropic glutamate receptor like, Secretin receptor like. 10 of 19 Examples of rhodopsin like GPCRs there are lots - all 5-HT except 5-ht3. Noradrenaline receptor, mACh, opioid, dopamine 11 of 19 Examples of metabotropic glutamate receptor like mGlurs 1-8, gabaA 12 of 19 Examples of secretin receptor like VIP, Parathyrod hormone receptors 13 of 19 Structure of rhodopsin like receptors 7 transmembrane domains with a ligand binding site on TMD 4. 14 of 19 Structure of mGlur-like 7 transmembrane domain, with LBS on N terminal extracellar domain 15 of 19 Families of intrinsic enzyme receptor families. Receptor tyrosine kinases, receptor guanylate cyclase 16 of 19 Example of RTK Insulin receptor, nerve growth factor receptor TrkA 17 of 19 Example of receptor guanylate cyclase atrial natriuretic peptide recetpor 18 of 19 How do intrinsic enzyme receptors usually function dimerisation, autophosphorylation, and substrate phosphorylation 19 of 19
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