basic drug pharmacology

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  • Created by: anna888
  • Created on: 28-01-23 14:53
describe bond nature of ligand to receptor
atleats 3 point attachment, covelnat bonds irreversible
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define agonist
ligand which interacts with a receptor to produce an observable biological response
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what is the ed50 on dose-response curve
effective dose, dose which gives 50% of the maxium repsonse
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define a partial agonist, hat does it look like on dose-response curve
acts same receptor as agonist but regardless of dose it cant produce the same max response as agonist.curve lies below agonist
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describe inverse agonist
acts on same receptor as agonist but inverse effect
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define spare receptor effect
full receptor occupancy not required for max biological effect
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define intrinsic activity
proportionality constant measuring the ability of the agonist to activate the receptor compared to the maximally active compound being studied
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define antagonist
inhibits agonist effect, but has no biological activity of its own
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describe competivie antagonist and its effect on agonist dose-response graph
binds to same site as agonist reversibly. conc of agonist must increase in presense of antagonist to produce same response. graph shifts to right
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describe non competive antagonist and its effect on dose-response graph of agonist
binds to same site as agonist irreversibly. when intoduced with agonist graph, even an increase in dose/con of agonist wont produce as equal response as to without the antagonist. grah shifts to the right and down as non competivie antagonist prevents ag
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define hetroreceptor
receptor which regulates the synthesis/release of chemicals other than its own ligands
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define autoreceptor
macromolecule which regulates the release of its own ligand
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receptor up vs down regulation
up- agonist which increases receptor numbers. down- agonist which decreases the receptor numbers
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define affinity
the ability of a drug to combine with a receptor, proportional to the constant KD
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define efficacy
measure of the physiological effect resulting from the drug binding to the receptor
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define potency
the dose of a drug required to produce a spefici effect of a give magnituded. effected by efficacy and affinity, the lower the ED50 the more potent the drug
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Card 2

Front

define agonist

Back

ligand which interacts with a receptor to produce an observable biological response

Card 3

Front

what is the ed50 on dose-response curve

Back

Preview of the front of card 3

Card 4

Front

define a partial agonist, hat does it look like on dose-response curve

Back

Preview of the front of card 4

Card 5

Front

describe inverse agonist

Back

Preview of the front of card 5
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