enzyme linked receptors

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Created by: anna888
Created on: 04-11-22 19:51

what occurs in dimerization

two halfes of a receptor jpined together

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main function of receptor guanyly cyclase

converts GTP-cGMP to activate downstream kinases

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mechanism of guanylyl cyclase

1. signal binds, conformational change in receptor causing dimerizaton and activation 2.guanylyl cycase domain activated on receptor so cGMP is prouduced

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where is receptor guanylyl cyclase found

relaxation of smooth muscle and dilates blood vessles

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main function/structure of serine/theronine (ser/thr) kinase

has type i and type ii sections- ternary complex. ser/thr domains phosphorilate protiens

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mechanism of action ser/thr kinase

1. ligand binds to type ii 2.dimerization of type i and type ii 3.type ii phosphorilates type i activating ser/thr domain on type i which phorphilate protiens

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wher is ser/thr kinase receptors found

relates to cell proliferation (cclin CDK activation at checkpoints)

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main function of receptor tyrosine kinases

phosphorliates themselves/other protiens

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mechanism of action of tryosine kinases

. ligand binds- dimerization 2.tryosine kinase domains phosphoilate eachother creating phosphotryosine motifs 3. motifs activate other molecules

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where is tryosine kinase receptors found

insulin mediated glucose uptake

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main funtion/struvture of tryosine kinase associated receptors

no kinase domain on receptor- associated tryosine kinase protiens. rest same as tryosine kinase receptors

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main function/structure of receptor tryosine phosphatase

dephospholrates protiens, not a dimer receptor

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mechanism of receptor tryosine phosphatase

1. ligand binds, activates tryosine phosphate domains. 2. protiens dephosphorilated-regulates downstreaming in cell signals

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where are receptor tryosine kinases found

maturation of lymphocytes

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Other cards in this set

Card 2

Front

main function of receptor guanyly cyclase

Back

converts GTP-cGMP to activate downstream kinases

Card 3

Front

mechanism of guanylyl cyclase

Back

Card 4

Front

where is receptor guanylyl cyclase found

Back

Card 5

Front

main function/structure of serine/theronine (ser/thr) kinase

Back

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enzyme linked receptors