Cell signalling
- Created by: Xena_H
- Created on: 12-10-20 23:37
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- Ways in which receptor signals are switched off
- Receptor down-regulation
- Receptor and ligand are uptakes by an endosome
- Both the receptor and ligand are engulfed by lysosomes for degradation
- Receptor and ligand are uptakes by an endosome
- Receptor Sequestration
- This is when the ligand and receptor are uptakes by an endosome. The low pH in the endosome causes the ligand to dissociate.
- This stops the signal. The receptor can be recycled back to the membrane but the ligand is taken to lysosomes for degradation.
- This is when the ligand and receptor are uptakes by an endosome. The low pH in the endosome causes the ligand to dissociate.
- Receptor inactivation
- An inhibiting molecule will bind to the receptor preventing it from passing the signal
- In RTKs, the action of phosphotaseswill inhibit enzymatic activity.
- An inhibiting molecule will bind to the receptor preventing it from passing the signal
- Inactivation of signalling proteins
- An inhibitor will bind to a signalling protein, inactivating intracellular proteins.
- Production of inhibitory proteins
- Some molecules further downstream will produce an inhibitory protein which will travel up-stream and inhibit a molecule
- Receptor down-regulation
- This is when the ligand and receptor are uptakes by an endosome. The low pH in the endosome causes the ligand to dissociate.
- This stops the signal. The receptor can be recycled back to the membrane but the ligand is taken to lysosomes for degradation.
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