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GPCRs

• the largest family of intergral membrane proteins
• they recognise a diverse range of ligands from the peptides, lipids, amino acids to photons
• through receptor signal transduction able to activate G-proteins and beta-arrestins
• share a common architecture 

GPCR Taxonomy 

• Glutamate - like GPCR
• Rhodopsin- like GPCR
• adhesion- like GPCR 
• frizzled -like receptors
• secretin -like GPCR

GLutamate like receptors

characteristic:

• largest and most sophisticated N-terminal domain
• contains 'venus fly trap' (VFT)
• some receptors contain a cystiene rich domain (CRD)
• can form hetero and homo dimers

family members

• glutamate receptors
• GABA receptors
• calcium sensing receptor
• taste receptor type 2

Rhodopsin - like GPCR

• comprises of more than 90% of the gpcr super-family
• the family have been broken down further into 4 sub-groups (a,b,y,6)
• the most well understood and studied 

typical characteristics

• short N-terminus
• Key motifs - DRY (TM3), NSXXNPXXY (TM7)
• palmitoylated cystiene located in the carboxyl-tail

examples of family members

• phodopsin
• histamine receptors
• dopamine receptors
• opoid receptors
• B2-adregenic receptor

adhesion like receptors

• have long N-terminus which is heavily glycosylated
• the N-terminus is rigid and sticks out of the cell and…