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  • Created by: jo bill
  • Created on: 22-12-14 12:48


  • the largest family of intergral membrane proteins
  • they recognise a diverse range of ligands from the peptides, lipids, amino acids to photons
  • through receptor signal transduction able to activate G-proteins and beta-arrestins
  • share a common architecture 

GPCR Taxonomy 

  • Glutamate - like GPCR
  • Rhodopsin- like GPCR
  • adhesion- like GPCR 
  • frizzled -like receptors
  • secretin -like GPCR

GLutamate like receptors


  • largest and most sophisticated N-terminal domain
  • contains 'venus fly trap' (VFT)
  • some receptors contain a cystiene rich domain (CRD)
  • can form hetero and homo dimers

family members

  • glutamate receptors
  • GABA receptors
  • calcium sensing receptor
  • taste receptor type 2

Rhodopsin - like GPCR

  • comprises of more than 90% of the gpcr super-family
  • the family have been broken down further into 4 sub-groups (a,b,y,6)
  • the most well understood and studied 

typical characteristics

  • short N-terminus
  • Key motifs - DRY (TM3), NSXXNPXXY (TM7)
  • palmitoylated cystiene located in the carboxyl-tail

examples of family members

  • phodopsin
  • histamine receptors
  • dopamine receptors
  • opoid receptors
  • B2-adregenic receptor

adhesion like receptors

  • have long N-terminus which is heavily glycosylated
  • the N-terminus is rigid and sticks out of the cell and…


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