Physiology lecture 2

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Where is the erythrocytes formed and broken down? How long is the life span?
Formed in the bone marrow, broken down in the spleen. Life span 120 days
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What are small RBCs called? and where would they be found?
Microcytic - found in people with iron deficiency anaemia
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What are large RBCs called? and where would they be found?
Macrocytic - found in people with folate deficiency anaemia
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What is the structure of Haemoglobin?
Each global has 1 attached haem group. Each haem group consists of a porphyrin ring that contains 1 atom of iron
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Hb in most adults =
2 x alpha, 2 x beta
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Hb in some adults =
2 x alpha, 2 x delta
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Hb in foetuses =
2 x alpha, 2 x gamma
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What happens in CO poisoning?
It preferentially binds to Hb
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What happens in alpha thalassemia?
Excess beta chains causes unstable tetramers
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What happens in beta thalassemia?
Excess alpha chains, do not form tetramers and high concentrations form toxic aggregates
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What happens in sickle cell anaemia?
Change of glutamic acid to valine. The Hb formed polymerises at low pO2. RBCs deform. Causes schema and infarction
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Card 2

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What are small RBCs called? and where would they be found?

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Microcytic - found in people with iron deficiency anaemia

Card 3

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What are large RBCs called? and where would they be found?

Back

Preview of the front of card 3

Card 4

Front

What is the structure of Haemoglobin?

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Card 5

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Hb in most adults =

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