Pharmacology lecture 11

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What are the noradrenergic receptors?
alpha 1 and 2. Beta 1, 2 and 3
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What type of receptors are alpha and beta? How fast are their responses?
G-protein coupled receptors. Slow (seconds)
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What are the effects of stimulating alpha 1 receptors?
Pupils dilate / Airways in lungs dilate / HR increases / Blood vessels to limb muscles dilate / Blood vessels to visceral organs and skin constrict / Brain activity general alertness
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What are the effects of stimulating alpha 2 receptors?
Inhibition of neurotransmitter release (presynaptic receptor)
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What are the effects of stimulating beta 1,2 receptors?
Pupils dilate / airways in lungs dilate / HR increase and force / blood vessels to limb muscles dilate / blood vessels to visceral organs and skin constrict / brain activity general alertness
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What are the effects of stimulating beta 3 receptors?
All same as b1/2, INCREASE lipolysis
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What is the main effect of alpha 1?
Smooth muscle and vaso-constriction
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What is the main effect of alpha 2?
Inhibition of neurotransmitter release
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What is the main effect of beta 1?
Increase cardiac rate and force
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What is the main effect of beta 2?
Bronchodilation
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What is the main effect of beta 3?
Lipolysis and increased metabolism
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Name a beta 1 agonist and what does it treat?
Dobutamine. Heart failure (Increases cardiac rate and force)
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Name an alpha 2 agonist and how is it used?
Clonidine (inhibits NA release). Used for hypertension. Treat withdrawal symptoms
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Name a beta 2 agonist and what does it treat?
Salbutamol (bronchodilation). Treat asthma
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Name a beta 1,2 antagonist and how is it used?
Propranolol (decreases CO2 and O2 demand, bronchoconstriction) treat hypertension and angina
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Name a beta 1 antagonist and how is it used?
Atenolol. Treat hypertension and angina
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Name a beta 2 antagonist and how is it used?
Timolol (ciliary contraction, decreased intraocular pressure). Treat glaucoma
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Name an alpha 1 antagonist and how is it used?
Prazosin (vasodilation and decreased vascular resistance). Treat hypertension
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How does adrenaline have to be given to a patient? Why?
By injection (either subcutaneous or intramusic) because its destroyed in the gut.
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What does an injection of adrenaline subcutaneously do?
Can prolong and isolate local anaesthetia
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What does an injection of adrenaline intramusic do?
Treat anaphylactic shock
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What receptor stimulates water electrolytes secretions?
alpha 1
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What drug as the side effect: Xerostomia? and how?
Clonidine. Inhibits NA release
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What drug disrupts storage of NA in synaptic vesicles?
Reserpine
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What drug blocks monoamine oxidase (metabolises NA)?
Tranylcypramine
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What drugs can block the re-uptake of NA and so prolong the action of NA?
Amphetamine, Reboxetine, Cocaine
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Card 2

Front

What type of receptors are alpha and beta? How fast are their responses?

Back

G-protein coupled receptors. Slow (seconds)

Card 3

Front

What are the effects of stimulating alpha 1 receptors?

Back

Preview of the front of card 3

Card 4

Front

What are the effects of stimulating alpha 2 receptors?

Back

Preview of the front of card 4

Card 5

Front

What are the effects of stimulating beta 1,2 receptors?

Back

Preview of the front of card 5
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