What type of receptors are alpha and beta? How fast are their responses?
G-protein coupled receptors. Slow (seconds)
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What are the effects of stimulating alpha 1 receptors?
Pupils dilate / Airways in lungs dilate / HR increases / Blood vessels to limb muscles dilate / Blood vessels to visceral organs and skin constrict / Brain activity general alertness
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What are the effects of stimulating alpha 2 receptors?
Inhibition of neurotransmitter release (presynaptic receptor)
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What are the effects of stimulating beta 1,2 receptors?
Pupils dilate / airways in lungs dilate / HR increase and force / blood vessels to limb muscles dilate / blood vessels to visceral organs and skin constrict / brain activity general alertness
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What are the effects of stimulating beta 3 receptors?
All same as b1/2, INCREASE lipolysis
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What is the main effect of alpha 1?
Smooth muscle and vaso-constriction
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What is the main effect of alpha 2?
Inhibition of neurotransmitter release
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What is the main effect of beta 1?
Increase cardiac rate and force
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What is the main effect of beta 2?
Bronchodilation
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What is the main effect of beta 3?
Lipolysis and increased metabolism
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Name a beta 1 agonist and what does it treat?
Dobutamine. Heart failure (Increases cardiac rate and force)
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Name an alpha 2 agonist and how is it used?
Clonidine (inhibits NA release). Used for hypertension. Treat withdrawal symptoms
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Name a beta 2 agonist and what does it treat?
Salbutamol (bronchodilation). Treat asthma
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Name a beta 1,2 antagonist and how is it used?
Propranolol (decreases CO2 and O2 demand, bronchoconstriction) treat hypertension and angina
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