inhaled route

Created by: anna888
Created on: 08-03-23 15:21

advantages

1. rapid so less side effects as smaller dose can be given 2. aviods gi so no enzyme degradation 3. aviods 1st pass so faster

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disadvantages

1.costly 2. difficult to use 3. mucocillary clearance means reduced retention time

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3 stages of particle absorbtion

deposition dissolution absorbtion

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describe pateint factors effecting deposition

lung capacity, coordination of button and inhalation, breathe holding

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describe physiochemcial factor effecting depositon

aerodnamic features of the particle, size and shape of particle

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describe inertial impaction

larger particles, moving at high momentum, collide with upper airway wall

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describe graviation sedimentaion

mid size particles - 1-5 micrometers- depends on particle size and density, in lower airway

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describe brownian movement

small partciles bombardded by random gas molecucles causing brownian motion and lower airway/ aveoilar wall collsion

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describe dissolution

dissolves in mucas. if not missolved in 24 hours the particle will be eliminated by either swallowing or macrophage destruction in the aveoili due to mucocillary clearance

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describe absorbtion

only occurs if dissolution occurs before mucocillary clearnace. lipohillic drugs better, depends on log p

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what are 3 cuurent tech for inhalation route

1.pMDIs- pressuried metered dose inhaler. 2. DPIs- dry powder inhalers 3. nebulisers

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Other cards in this set

Card 2

Front

disadvantages

Back

1.costly 2. difficult to use 3. mucocillary clearance means reduced retention time

Card 3

Front

3 stages of particle absorbtion

Back

Card 4

Front

describe pateint factors effecting deposition

Back

Card 5

Front

describe physiochemcial factor effecting depositon

Back

View more cards

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inhaled route