aerodnamic features of the particle, size and shape of particle
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describe inertial impaction
larger particles, moving at high momentum, collide with upper airway wall
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describe graviation sedimentaion
mid size particles - 1-5 micrometers- depends on particle size and density, in lower airway
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describe brownian movement
small partciles bombardded by random gas molecucles causing brownian motion and lower airway/ aveoilar wall collsion
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describe dissolution
dissolves in mucas. if not missolved in 24 hours the particle will be eliminated by either swallowing or macrophage destruction in the aveoili due to mucocillary clearance
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describe absorbtion
only occurs if dissolution occurs before mucocillary clearnace. lipohillic drugs better, depends on log p
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