Acute Inflammation and Wound Healing

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Acute Inflammation and Wound Healing
-What is Acute Inflammation
-What is Wound Healing & 4 stages
-Causes
-Purpose
-Hemostasis
-Inflammation (Neutrophils & Macrophages)
-Proliferation
-Remodeling
-Possible Outcomes with Acute Inflammation
What is Acute Inflammation?

Acute inflammation is the body’s normal tissue response to injuries, foreign bodies and other outside factors. It is the defense mechanism of body tissue reacting to kick start the healing process.

Hallmarks-Redness/Warmth/Sw
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Wound Healing- 4 stages

Wound healing refers to a living organism's replacement of destroyed or damaged tissue by newly produced tissue.

-Hemostasis (stop bleeding)
-Inflammation (new framework)
-Proliferation (pulls wound closed)
-Remodeling (final
Causes

-Injury/Trauma
-Burns/Frostbite/Radiation
-Chemical irritants/poisons
-Infection
-Allergic reaction
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Purpose

To eliminate harmful agent
To prevent the spread of harmful agent
To remove necrotic cells & tissue
To initiate the repairing process
Hemostasis

Hemostasis is your body's natural reaction to an injury that stops bleeding and repairs the damage.

The initial damage to blood vessels triggers two reactions: Kinin and coagulation (pain and blood clotting)
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Inflammation

Cellular Invasion (Phagocytosis)

Neutrophils
Macrophages
Neutrophils

- Type of white blood cell (leukocytes)
-First to arrive
-Remove bacteria and debris
-Release additional signaling to recruit macrophages
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Macrophages

-Specialized cells involved in the detection and destruction of bacteria and other harmful organisms.
-Secrete hormones (cytokines) that attract immune system cells to the site and activate cells involved in tissue repair
Proliferation

-The wound is 'rebuilt' (Fibroblast)
-New granulation tissue (Collagen synthesis)
-New network of blood vessels develop (Angiogenesis)
-Wound closure (Contraction)
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Remodeling

-Final phase of the wound healing process
-Occurs concurrently with granulation tissue formation.
-Longest phase
-The success of this phase depends on
Degree of injury/Tissue type/Patient factors
Possible Outcomes with Acute Inflammation

No long term effects
-Removal of stimulus
-Normalization of vascular permeability
-Apoptosis of inflammatory cells
-Restoration of normal function
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Other cards in this set

Card 2

Front

Causes

-Injury/Trauma
-Burns/Frostbite/Radiation
-Chemical irritants/poisons
-Infection
-Allergic reaction

Back

Wound Healing- 4 stages

Wound healing refers to a living organism's replacement of destroyed or damaged tissue by newly produced tissue.

-Hemostasis (stop bleeding)
-Inflammation (new framework)
-Proliferation (pulls wound closed)
-Remodeling (final

Card 3

Front

Hemostasis

Hemostasis is your body's natural reaction to an injury that stops bleeding and repairs the damage.

The initial damage to blood vessels triggers two reactions: Kinin and coagulation (pain and blood clotting)

Back

Preview of the back of card 3

Card 4

Front

Neutrophils

- Type of white blood cell (leukocytes)
-First to arrive
-Remove bacteria and debris
-Release additional signaling to recruit macrophages

Back

Preview of the back of card 4

Card 5

Front

Proliferation

-The wound is 'rebuilt' (Fibroblast)
-New granulation tissue (Collagen synthesis)
-New network of blood vessels develop (Angiogenesis)
-Wound closure (Contraction)

Back

Preview of the back of card 5
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