Immunology- Complement

Created by: Ruth
Created on: 03-02-13 14:53

What are the three pathways of complement activation?

Lectin, Classical and Alternative

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What is the lectin pathway?

Microbial surfacves have mannose on the surface which is recognised by MASP1 and MASP2. THese enzymes cleave C2 and C4 to form C4bC2a which is a C3 convertase

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What is the classical pathway?

Antibodies cause C1q,C1r and C1s to bind. C1q,r,s cleaves C4 and C2 to form C4bC2a.

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What is the alternative pathway?

Involves four serum proteins to result i nteh production of C3 convertase C3bBb.

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What are the four proteins involved in the alternative pathway?

C3b, factors B & D and properdin.

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What are the C3 convertases?

C4bC2a, C3bBb

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What are the key outcomes of Complement activation?

C3a and C5a trigger mast cell degranulation and chemotaxis INFLAMMATION. C5b with C6,C7,C8 and C9 to form the membrane attack complex C3b binds to receptors on phagocytes and opsonises the pathogen leading to PHAGOCYTOSIS.

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What are the other major outcomes of complement?

B cell activation by C3a, Clearance of immune complex by C3b, Mast cell degranulation, Chemotaxis and opsonisation

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Other cards in this set

Card 2

Front

What is the lectin pathway?

Back

Microbial surfacves have mannose on the surface which is recognised by MASP1 and MASP2. THese enzymes cleave C2 and C4 to form C4bC2a which is a C3 convertase

Card 3

Front

What is the classical pathway?

Back

Card 4

Front

What is the alternative pathway?

Back

Card 5

Front

What are the four proteins involved in the alternative pathway?

Back

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Immunology- Complement