Principles of Immunology, lecture 3, antibodies

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  • Antibodies
    • IgG
      • Secondary immune response
      • Opsonisation
      • Complement activation
      • Transplacental passage
      • Blood: 8-16g/L
      • Monomer
        • IgM
          • Primary immune response
          • Complement activation
          • Agglutination
          • Only found in vascular system
          • Blood: 0.5-2g/L
          • Molecular Weight: 900 KDaltons
          • Pentamer
          • Serum concentration: 1.5g/L
        • IgA
          • Secretions
            • Trimer
          • High levels in first breast milk
            • Transplacental passage
          • Dimer
            • Secretions
              • Trimer
          • Tetramer
          • Molecular Weight: 150-600 KDaltons
          • Serum concentration: 1.5-4g/L
      • Molecular Weight: 150 KDaltons
      • Serum: 0.5-9g/L
    • IgM
      • Primary immune response
      • Agglutination
      • Only found in vascular system
      • Blood: 0.5-2g/L
      • Molecular Weight: 900 KDaltons
      • Pentamer
      • Serum concentration: 1.5g/L
    • IgA
      • High levels in first breast milk
        • Dimer
          • Tetramer
          • Molecular Weight: 150-600 KDaltons
          • Serum concentration: 1.5-4g/L
        • IgE
          • Protection against parasitic worm infestation
          • Serum: 0.0003g/L
          • Allergies
          • Monomer
            • Molecular Weigh: 190 KDaltons
            • no useful antibodies in blood
              • serum: 0.015-0.04g/L
          • IgD
            • no useful antibodies in blood
              • serum: 0.015-0.04g/L
            • membrane bound
              • same variable regions
            • Role a mystery

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