Antibody dependent cellular cytotoxicity. A cytotoxic reaction in which killer cells and other cells bearing Fc receptors recognize target cells via specific antibodies.
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alternate pathway
A series if enzyme reactions triggered by foreign surfaces leading the generation of the alternate C3 convertase (C3bBb).
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anaphylatoxins
Complement fragments with the ability to stimulate mast cell degranulation.
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arylsulphatase
An enzyme which degrades SRS-A, a mixture of LT and PG; produced and released by eosinophils.
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C' activation
The process of initiating the complement cascade.
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cascade reactions
An interlinked series of enzyme reactions in which the products of one reaction catalyze a second reaction, and so forth.
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chemotactic factors
Molecules which attract a specific type of cell to the point of highest concentration, usually the point of generation of the factors.
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classical pathway
A series of enzyme reactions triggered by the binding of C1 to an immune complex, leading to the generation of the classical C3 convertase (C42)
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complement (C')
A complex, linked enzyme and aggregating protein system that is activated by factors such as the combination of antigen and antibody and results in a variety of biological consequences including cell lysis and opsonization.
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cytolysis
The lysis of cells, either specifically or nonspecifically.
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histaminase
An enzyme which degrades histamine.
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inflammation
A complex set of reactions caused by cells and soluble factors which are characterized by rubor, calor, tumor, dolor (redness, heat, swelling, and pain).
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kinins
Vasoactive peptides.
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lethal hit
Cell death caused by direct contact with an effector cell.
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leukotrienes (LT)
Metabolites of arachidonic acid produced by the actions of lipoxygenase.
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lymphotoxin
Cytotoxic factors released by lymphocytes.
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opsonin
A substance which facilitates the phagocytosis of foreign particles.
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perforins
A family of proteins that has the ability on polymerization to form tubes which insert into cell membranes and provoke cell lysis.
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prostaglandins (PG)
Metabolites of arachidonic acid produced by cyclooxygenase.
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SRS-A
Slow reacting substance of anaphylaxis. A mixture of leukotrienes LT-C, LT-D, LT-E, and prostaglandins, which are late phase products released by mast cells and basophils.
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terminal (attack) pathway
The final cascade sequence of complement which results in lysis. This may be initiated by either the classical or the alternate pathways.
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tumor necrosis factors (TNF)
Products produced by macrophage and lymphocytes that can exert a direct toxic effect on neoplastic cells.
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vasoactive factors
Molecules which effect the vascular permeability and/or the level of vasodilation/vasoconstriction.
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Other cards in this set
Card 2
Front
A series if enzyme reactions triggered by foreign surfaces leading the generation of the alternate C3 convertase (C3bBb).
Back
alternate pathway
Card 3
Front
Complement fragments with the ability to stimulate mast cell degranulation.
Back
Card 4
Front
An enzyme which degrades SRS-A, a mixture of LT and PG; produced and released by eosinophils.
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