The tissue that supports, binds or seperates more specialised tissue in the body.
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What are the main constituents of connective tissue?
Fibroblasts and ECM.
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What is the ECM?
Extracellular Matrix. It consists of amorphus ground substance made up of glycosamnoglycans(GAGs) embedded in elastic, collagenius and reticular fibres(fibrillar proteins). The basement membrane is also part of this.
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What is a connective tissue?
Bone, cartilage, tendons, ligaments, adipose areolar and elastic tissue
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What are GAGs?
Glycosaminoglycans are large polysaccharide chains with repeating units.
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What are proteoglycans?
GAGs covalently bonded to proteins which are capable of maintaining a large hydration space in the ECM.
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What does connective tissue develop from embreyologically?
Mesenchyme.
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What are fibroblasts?
Cells which secrete ECm components in most tissues.
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What cells secrete ECM in cartilage?
Chondrocytes
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What other specialised ECM secreting cells are there?
Osteocytes, adipocytes and myofibroblasts.
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What are the four main proteins in ECM?
Collagen, fibrillin, elastin, fibronectin
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What is collagen?
A family of proteins which are the most important of the extracellular fibrillar proteins.
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How many types of Collagen are there?
11. You need to worry about I-V.
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What is type I collagen?
30% body protein, including loose fibrous tissue, bone, ligaments and skin.
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What is Tpye II collagen?
Hyaline and elastic cartilage making up vertebral disks and vitreous of the eye.
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