Difference between single and multiunit smooth muscle
Multiunit: each individual cell respond on its own Single: neurotransmitters released between gap junctions.
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What is tonic and phasic contractions
Tonic is sustained contraction whilst phasic in sometimes contracted and sometime relaxed.
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Whats the major difference between smooth muscles and the other muscles in terms of the AP
Smooth muscles don't need an action potential, can contract with a slight change in the membrane potential.
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How are Ca2+ release from SR
A neurotransmitter binds to a G-protein coupled receptor. This sets of a sgnalling pathway which release IP3. This diffuses through sarcoplasm and bind to receptors on SR. Calcium channel opens.
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How do smooth muscles contract
Ca2+ released from SR and bind to calmodulin in sarcoplsm to form calcium-camlodulin complex. This converts and inactive orm of myosin light chaain kinase into active one (MLCK).
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Continued
The MLCK phosphorylates the mysoin chain (ADP to ATP) which enables the mysoin head groups to bind to the actin. Once attached the cross-bridge cycle continues
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What is the latch state of smooth muscle and why does it happen
An adaption that allows sustained smooth muscle tone with a low rate of cross-bridge cycling. Occurs when some of the cross-bridges become dephosphorylated and detach
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What kind of contraction is this
Thick-filament regulated
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Other cards in this set
Card 2
Front
What are smooth muscle contractions controlled by
Back
ANS
Card 3
Front
Difference between single and multiunit smooth muscle
Back
Card 4
Front
What is tonic and phasic contractions
Back
Card 5
Front
Whats the major difference between smooth muscles and the other muscles in terms of the AP
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