What's In Medicine Revision Guide (OCR B Salters)

A multi purpose revision booklet that uses the OCR B specification to give focused and detailed information and knowledge required for the What's in medicine section.

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Page 1

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WHATS IN MEDICINE?
How To Use this Booklet:

This booklet has been created by addressing all the points on the OCR B
salters specification for the section, what's in medicine. I advise reading
through the Book, highlighting or underlining words written in ALL
CAPITALS. I also suggest making a spider…

Page 2

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If A- is the base, then HA is it's conjugate acid!

If H2O is the base, then H30+ is it's conjugate acid!

If H3O+ is the acid, then H20 is it's conjugate base!

Substances that can act as an acid OR a base are described as AMPHOTERIC! H2O
is an…

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Page 4

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Recall the physical properties of Ionic, Covalent metallic and simple
molecular structures.

TYPE OF MELTING POINT SOLUBILITY IN CONDUCTIVITY
BONDING WATER OF ELECTRICITY
IONINC High Soluble When molten
METALLIC High Not soluble Yes
COVALENT High Not soluble No
SIMPLE Low Not soluble No
MOLECULAR


C) Describe and explain the acidic…

Page 5

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E) Describe the following properties/tests of phenols.

ACIDIC NATURE More acidic than alcohols and water, but less so than
carboxylic acids!

REACTIONS WITH ALKALIS (excluding carbonates) They react with bases to
form corresponding salts and water.

NEUTRAL IRON CHLORIDE (III) SOLUTION This is used to test for phenols. If
a…

Page 6

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As already mentioned, aldehydes can be oxidised further, under the same




conditions, to form carboxylic acids!




REDUCTION

Both Aldehydes and Ketones can be REDUCED back to their original alcohols as
via REDUCTION reactions! A powerful reducing agent in SODIUM
TETRAHYDRIDOBORATE (III), NaBH4, is used as the reaction does not take…

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H) Recall the meaning of the concept `Atom Economy' and understand
that most reactions used in chemical synthesis can be classified as:
rearrangement, addition, substitution, elimination; understand that a
condensation reaction is a addition followed by elimination; classify a
given reaction using these terms.

Remember that rearrangement and addition reactions…

Page 8

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4) Locate any spots with IODINE, NINHYDRIN or Under a UV lamp.

5) Match the heights reached or Rf values with those of known compounds.




Recall




J) Recognize and write formulae for members of the following
homologous series: Diols, dicarboxylic acids, diamines, phenols, acyl
chlorides, acid anhydrides and esters.

Page 9

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DICARBOXYLIC ACID




DIAMINES




ACYL CHLORIDES

ACID ANHYDRIDE
ESTERS




K) Understand that testing a medicine involves clinical trials, which
answer certain questions about a potential new drug.

PHASE 1 TRIALS This is the first time that medicines are administrated to
humans, usually in studies of healthy, informed volunteers conducted under
the…

Page 10

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groups to establish whether the compound is suitable for further study or
should be abandoned. Usually 200-400 people.

PHASE 3 TRIALS At this stage, the medicine is likely to be compared with a
placebo and possibly another medicine already used for the disease under
investigation to provide a reference standard.…

Comments

iruka

Thank you so much :) XX

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