Reward & Addiction


	Reward & Addiction
	Causes Animal recieving a reward... Dopamine antagonist (pimozide)... Electrical self-stimulation of VTA... Low doses of D2 antagonist in drug self-adminestration... Conditioned placed preference... Conditioned induced craving...	Effects Increased dopamine in nucleus accumbent (mesolimbic pathway) Motivation is blocked > D2 is involved in motivation Increases lever pressing to recive more stimulation Animal presses harder to get more D2 to compete with antagonist Rats learn the association between reward (food/cocaine) so spend longer in CS+ chamber. Rats associate the light on w/ reward > Conditioned release of D2 when lights on so it becomes motivational
	Overall summary psychopharmacological experiments which provide evidence for a role of dopamine in reward and reinforcement.

Increased dopamine in nucleus accumbent (mesolimbic pathway)
Motivation is blocked > D2 is involved in motivation
Increases lever pressing to recive more stimulation
Animal presses harder to get more D2 to compete with antagonist
Rats learn the association between reward (food/cocaine) so spend longer in CS+ chamber.
Rats associate the light on w/ reward > Conditioned release of D2 when lights on so it becomes motivational

psychopharmacological experiments which provide evidence for a role of dopamine in reward and reinforcement.

Get Revising