TB10 P&C Lecture 2; Olfaction and taste

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  • Created by: mint75
  • Created on: 24-05-16 11:11

1. Each OSN...?

  • Receive input from glomeruli
  • Are resistant to damage due to highly internalised structure
  • Expresses just one type of receptor
  • Has broad non-specific connections
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2. What do turbinates do?

  • Part of the olfactory sensory neuron, each OSN has a single type of odor receptor.
  • Force air flow against epithelium
  • Oderant molecules 'stick to' this when air comes into contact with it
  • Covered in mucus and is fragile

3. What is the core concept of vibration theory?

  • Molecules with the same IR vibrational spectrum should smell similar, same shape diff vibrations smell different. Bond energies determine activation level
  • A two-stage theory. Molecules must be the right shape to bond to receptor sites but bond energies determine final activation level.
  • Receptor specificity is based on molecular structure. Oderants must have the right shape to activate the receptor, there is a certain receptor for each molecule

4. Olfactory cilia...?

  • Force air flow against epithelium
  • Part of the olfactory sensory neuron, each OSN has a single type of odor receptor.
  • Oderant molecules 'stick to' this when air comes into contact with it
  • Covered in mucus and is fragile

5. How many seperate olfactory receptor genes are there?

  • 1000 but 60-70% of these are pseudogenes in humans
  • 5, much less than the genetics of mice

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