Dysfunction as there are intrusions during the day and abnormalities at night.
1 of 18
Vogel
Observed REM at the onset of narcoleptic patients (not usually till further in the cycle)
2 of 18
Siegal
In dogs - cataplaxy associated with brain cell activity in REM
3 of 18
HLA
HLA variant (found on white blood cells and helps to coordinate the immune response). More than 90% have this variant.
4 of 18
Mignot
Not all have this variant and it is also found in the general population
5 of 18
Hypocretin
Neurotransmitters that regulate sleep and wakefulness through interactions with the systems that regulate homeostatis and emotion. Usually 10,000-2,0000 but there is many missing in narcoleptics.
6 of 18
Lin
Mutation in a gene on chromosome 12 = disrupts the process of hypocretin
7 of 18
Nishino
Lower hypocretin in their cerebrospinal fluid
8 of 18
Mignot
Not genetic as is it rarely due to a gene and when one twin has narcolepsy - the other usually does not
9 of 18
Mignot
HLA variant affects the immune system which makes autoimmune conditions more likely - reduced levels of hypocretin.
10 of 18
Narcolepsy Centre
The key may be to inject hypocretin but this is relatively unstable - hypocretin producing cells.
11 of 18
Incomplete Arousal
Partly awake as they are engaged in activities usually associated with being awake. Delta and beta waves (incomplete arousal)
12 of 18
Risk Factors
Alcohol/stress/hormonal changes
13 of 18
Oliviero
System that normally inhibits more activity in SWS is not sufficiently developed in some childrena and underdeveloped in some adults.
14 of 18
Broughton
Prevalence of sleep walking in first degree relatives of an affected subject is at least 10x greater than in the normal population.
15 of 18
Lecendreux
50% concordance in MZ twins compared to 10-15% in DZ twins (possible gene).
16 of 18
Zedra
DSM - kept sleep walkers awake and found that by the second night the prevalence of sleep walking rose from 50-90%.
17 of 18
IDA
Has been used in legal cases but seen as 'insanity'.
18 of 18
Other cards in this set
Card 2
Front
Observed REM at the onset of narcoleptic patients (not usually till further in the cycle)
Back
Vogel
Card 3
Front
In dogs - cataplaxy associated with brain cell activity in REM
Back
Card 4
Front
HLA variant (found on white blood cells and helps to coordinate the immune response). More than 90% have this variant.
Back
Card 5
Front
Not all have this variant and it is also found in the general population
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