Sleep Disorders - Narcolepsy/Sleep Walking

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  • Created by: Liss.
  • Created on: 15-05-14 11:21
REM
Dysfunction as there are intrusions during the day and abnormalities at night.
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Vogel
Observed REM at the onset of narcoleptic patients (not usually till further in the cycle)
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Siegal
In dogs - cataplaxy associated with brain cell activity in REM
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HLA
HLA variant (found on white blood cells and helps to coordinate the immune response). More than 90% have this variant.
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Mignot
Not all have this variant and it is also found in the general population
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Hypocretin
Neurotransmitters that regulate sleep and wakefulness through interactions with the systems that regulate homeostatis and emotion. Usually 10,000-2,0000 but there is many missing in narcoleptics.
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Lin
Mutation in a gene on chromosome 12 = disrupts the process of hypocretin
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Nishino
Lower hypocretin in their cerebrospinal fluid
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Mignot
Not genetic as is it rarely due to a gene and when one twin has narcolepsy - the other usually does not
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Mignot
HLA variant affects the immune system which makes autoimmune conditions more likely - reduced levels of hypocretin.
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Narcolepsy Centre
The key may be to inject hypocretin but this is relatively unstable - hypocretin producing cells.
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Incomplete Arousal
Partly awake as they are engaged in activities usually associated with being awake. Delta and beta waves (incomplete arousal)
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Risk Factors
Alcohol/stress/hormonal changes
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Oliviero
System that normally inhibits more activity in SWS is not sufficiently developed in some childrena and underdeveloped in some adults.
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Broughton
Prevalence of sleep walking in first degree relatives of an affected subject is at least 10x greater than in the normal population.
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Lecendreux
50% concordance in MZ twins compared to 10-15% in DZ twins (possible gene).
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Zedra
DSM - kept sleep walkers awake and found that by the second night the prevalence of sleep walking rose from 50-90%.
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IDA
Has been used in legal cases but seen as 'insanity'.
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Other cards in this set

Card 2

Front

Observed REM at the onset of narcoleptic patients (not usually till further in the cycle)

Back

Vogel

Card 3

Front

In dogs - cataplaxy associated with brain cell activity in REM

Back

Preview of the back of card 3

Card 4

Front

HLA variant (found on white blood cells and helps to coordinate the immune response). More than 90% have this variant.

Back

Preview of the back of card 4

Card 5

Front

Not all have this variant and it is also found in the general population

Back

Preview of the back of card 5
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