Reduces vasodilation and oedema, reduced temperature in the hypothalamus
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What does a decrease in PGI2 do?
Reduce vasodilation and oedema, reduce sensitisation od nociceptive nerve endings to bradykinin, reduce headache pain due to vasodilation
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What is the mechanism of action of COX-2 inhibitors?
Selectively block the COX-2 enzyme and doing this reduces synthesis of prostagalndins responsible for tumor and calor in inflammation
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COX1 vs COX2?
COX1: constitutive, expressed in most tissue, housekeeping role in tissue
COX2: inducible, expressed in inflammatory cells when activated by cytokines, production of prostanoid mediators.
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What are the benefits of the selectivity of COX2?
COX 2 inhibitors have demonstrated to be associated with a significant reduction in the risk of upper and lowwer GI complications compared to general NSAIDs
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What are some unwanted effects of NSAIDs?
Reduce mucus secretion
Decrease glomerular filtration rate due to reduced blood flow, salt and water retention
Increase BP and prothrombotic
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What are some examples of selective COX2 inhibitors?
Celecoxib and etericoxib
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Other cards in this set
Card 2
Front
What are some examples?
Back
Aspirin
Salicylic acid
Naproxen
Card 3
Front
What does a decrease in PGE2 cause?
Back
Card 4
Front
What does a decrease in PGI2 do?
Back
Card 5
Front
What is the mechanism of action of COX-2 inhibitors?
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