Neoplasia

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1. Which of these is not true for malignant neoplasms?

  • The neoplasm does not have a true capsule and have an ill-defined border.
  • The nuclei are hyperchromatic and pleopmorphic.
  • The neoplasm is well-differentiated.
  • There are numerous mitotic figures within the neoplasm.
  • The growth rate of the neoplasm is relatively rapid.
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2. Which of these disorders of cell growth are potential precursors for neoplasms?

  • Hyperplasia, hypertrophy and metaplasia
  • Metaplasia, atrophy and dysplasia
  • Hyperplasia, metaplasia and dysplasia
  • Dysplasia, atrophy and hypertrophy
  • Hyperplasia, atrophy and hypertrophy

3. What is a proto-oncogene?

  • A normal gene that can undergo a mutation to become an oncogene
  • A gene that is responsible for inducing apoptosis
  • A gene which is inappropriately abnormally or excessively expressed in tumours and is responsible for their abnormal growth
  • A gene that protects a cell from one step on the path to cancer

4. Which of these does NOT form a genetic basis for carcinogenesis?

  • A genetic defect in the genes the regulate apoptosis (dominant or recessive)
  • A genetic defect in the genes which are responsible for DNA repair
  • A genetic defect machinery which produces proteins in the cell
  • Enhances expression of dominant growth promoting genes (oncogenes)
  • Loss or inactivation of recessive, growth inhibiting genes (tumour suppressor genes)

5. What is an adenoma?

  • A malignant neoplasm of cartilage
  • A benign neoplasm of glandular epithelium
  • A benign neoplasm of cartilage
  • A malignant neoplasm of glandular epithelium

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