Microbiology 2.5 (lecture 5)
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- Created by: LailaFrancis
- Created on: 17-02-23 13:27
a cytoplasmic membrane contains: select wrong answer
basic structure of 2 sugar derivatives connected in b1-4 linkages
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Peptidoglycan (murein) is Common to all types of bacterial cell wall and Composed of basic structure of 2 sugar derivatives connected in b1-4 linkages: select wrong one
N-acetyl glucronide acid (NAG)
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Peptidoglycan: select false statement
Cross linking of NAM with a tripeptide
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Peptidoglycan specifics: select false statement
b1-4 bond can be degraded by tetrapeptide
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Tetrapeptide contains what amino acids
D and L
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which amino acid essential for cross linking
3rd
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what is released during the cross linking step
Precursor form of the peptide has an extra D-ala
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Prefabricated subunits are assembled on the inside of the cell. Brought to the surface by what?
large phospholipid called bactoprenol and attached to the existing structure
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In Gram-positive bacteria, what forms multiple layers and often cross linked in 3 dimensions to give strong rigid cell wall
peptidoglycan
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what acidic polysaccaride is also present in the cell wall
Teichoic acid
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what residues does Teichoic acid contain
glycerophosphate or ribitol phosphate residues
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what overall charge does the cell surface have
negative
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Glycerol containing acids are bound to membrane lipids of Gram-positives are called what?
lipoteichoic acids
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what will Provide antigenic determinants (immune response)
Sugars, choline or D-alanine may be attached to the hydroxyls of the ribose or glycerol
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what protein will Present as fine processes called fimbriae and Protects from phagocytosis for group A streptococcus?
M protein
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in Protein A of S. aureus: what region does it bind
Binds Fc region of IgG
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Protein A of S. aureus competes w what for the Fc region of opsonising antibodies?
neutrophil receptors
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present in periplasmic space: select incorrect statement
cytoplasmic properties used to propel the movement of water outside the cell membrane
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outer membranes are unique to gram negative bacteria, select incorrect answer
provides space for osmotic granules to leave cell: removing toxins
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AKA endotoxin: Amphipathic molecule known as?
lipopolysaccharide (LPS)
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LPS is a powerful stimulator of the immune response: select incorrect statement
Stimulated to release IL3 and 6, tumour necrosis factor
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excess of LPS leads to what? (mainly)
septic shock
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3 structural sections in LPS:
Lipid A
Core polysaccharide
O polysaccharide.
what are the functions of lipid a
Lipid A
Core polysaccharide
O polysaccharide.
what are the functions of lipid a
anchored in the membrane:
Is responsible for the endotoxic activity
Very toxic to host
Released in large quantities when cells die
Consists of 6 fatty acid chains and 2 glucosamine residues
Is responsible for the endotoxic activity
Very toxic to host
Released in large quantities when cells die
Consists of 6 fatty acid chains and 2 glucosamine residues
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3 structural sections in LPS:
Lipid A
Core polysaccharide
O polysaccharide.
what are the functions of o antigen
Lipid A
Core polysaccharide
O polysaccharide.
what are the functions of o antigen
A long linear polysaccharide of 50-100 repeating saccharide units of 4-7 sugars per unit
Distinguishes serotypes of bacterial species
Distinguishes serotypes of bacterial species
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3 structural sections in LPS:
Lipid A
Core polysaccharide
O polysaccharide.
what are the functions of core polysaccharides
Lipid A
Core polysaccharide
O polysaccharide.
what are the functions of core polysaccharides
Branched and contains 9-12 sugars
Contains unusual sugar 2 keto-3-deoxy-octanate (KDO)
Core region constant for many species of bacteria
Contains unusual sugar 2 keto-3-deoxy-octanate (KDO)
Core region constant for many species of bacteria
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what facilitates transport into the cell? Roughly 100 on cell surface
10 angstrom (Å) diameter
10 angstrom (Å) diameter
Porin protein forming channels in the membrane
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Act as transport proteins for larger metabolites including: select incorrect answer
gram positive bacteria
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membrane pores: select incorrect statement
Permeable/ highly sensitive to antibiotics
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most well known acid-fast bacteria
Mycobacterium
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Mycobacterium: select incorrect answer
Encourages gram positive staining
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along w classification, what is another advantage cell walls have to man?
Provides selective toxicity for anti-microbials
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Other cards in this set
Card 2
Front
Peptidoglycan (murein) is Common to all types of bacterial cell wall and Composed of basic structure of 2 sugar derivatives connected in b1-4 linkages: select wrong one
Back
N-acetyl glucronide acid (NAG)
Card 3
Front
Peptidoglycan: select false statement
Back
Card 4
Front
Peptidoglycan specifics: select false statement
Back
Card 5
Front
Tetrapeptide contains what amino acids
Back
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