MHC Molecules

This is a short quiz covering the basics of MHC molecules and their role in the immune system. Information covered during semester 2 in my second year of a Biological Sciences undergrad.

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  • Created by: gemmmmma
  • Created on: 28-07-20 15:56
What is the role of an MHC molecule
To present processed antigen epitopes to T cells
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What cells can MHC molecules be found on?
Antigen presenting cells (APCs)
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MHC 1 molecules are found on...
All body cells
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MHC 2 molecules are found on...
Immune cells
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How can an MHC 2 be differentiated from MHC 1?
MHC 2 molecules have 2 alpha and 2 beta chains, MHC 1 have 3 alpha and 1 beta
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Which MHC molecule presents exogenous peptides?
MHC 2 molecules
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Which MHC molecule presents endogenous peptides?
MHC 1 molecules
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How to T cells bind to the peptides presented by MHCs?
The T cell receptor is complementary to anchor residues on the peptide.
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The interaction between TCRs and peptides can be described as...
Degenerate
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The genes HLA-A, HLA-B, HLA-C code for...
MHC 1 molecules
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The genes HLA-DP, HLA-DQ (and HLA-DR) code for...
MHC 2 molecules
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Why are the genes for MHCs the most polymorphous?
It provides a survival advantage for the whole population during mass infections
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The MHC molecules are encoded by....
co-dominantly expressed clusters (halotypes)
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Where are the areas of highest variability found on an MHC molecule?
Within the peptide binding groove
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CD4 co-receptors on CD4 cells recognise...
MHC 2 molecules
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CD8 co-receptors on CD8 cells recognise...
MHC1 molecules
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TCRs only exist alongside...
CD3 co-receptor
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What is the role of CD4 and CD8 co-receptors?
To increase the sensitivity of T cells by 100x
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What molecules are required for endogenous MHC1 processing
proteasome, ubiquitin, endoplasmic reticulum, TAAP
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What molecules are required for exogenous MHC2 processing
endosomes, lysosomes, golgi body, and CLIP
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Peptides are promiscuous, which means...
They can bind to multiple different MHC molecules
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Other cards in this set

Card 2

Front

What cells can MHC molecules be found on?

Back

Antigen presenting cells (APCs)

Card 3

Front

MHC 1 molecules are found on...

Back

Preview of the front of card 3

Card 4

Front

MHC 2 molecules are found on...

Back

Preview of the front of card 4

Card 5

Front

How can an MHC 2 be differentiated from MHC 1?

Back

Preview of the front of card 5
View more cards

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