immune system 3 0.0 / 5 ? Biologyimmune systemUniversityNone Created by: anna888Created on: 01-12-22 16:11 describe negative seletion in b cells if cells auntoreactive then apoptosis of the b cells 1 of 18 upon b cell activation, describe steps and locations lymphnode primary folicale, IgM produced. then goes to secondary folile where IgA and IgG and memory cells are produced 2 of 18 structure of t cell receptor alpha and beta polypeptide. constant and variable regions, cd3 and zeta chains for signal trandution and activation 3 of 18 t cell response? recognise short peptides on the mhc 4 of 18 describe mhc class 1 on all cells, peptide 8-10 aa, responds to intracellular virus atttack by cd8+ t cells 5 of 18 describe mhc class 2 antigen presnting cells eg macrophages and dendrites, over 13 aa on the peptide, cd4+ t helper cells, extrcellular pathogen 6 of 18 describe negive selection of t cells get rid of t cells which recognise and attack self mhc and self peptides 7 of 18 describe postive selection of t cells get rid of t cells which do not recognise self mhc or self peptides 8 of 18 what do the activation of t cells require co stimulatory molecules 9 of 18 describe features of cd8 activity cytotoxic, require high co stim levels, activated and kill 10 of 18 describe 2 methods to cd8 activation via non self peptides in mhc 1, or by cd4 cells 11 of 18 describe how cd8 cells kill 1. cytotoxic granuels(perforin),2. fas liagnd(proapoptoic) 3. help with inf gamma cytokines acting as nk cells 12 of 18 main point of cd4 activity release cytokines 13 of 18 what do th1 do attack intacellular bacteria and some virus. cytokines for macrophages 14 of 18 what do th2 do extracellular parsites and allergns. cytokines for b cells 15 of 18 what do th17 do extracelluklar bacteria and fungi. cytokines for neutrophills 16 of 18 what do thfr do stimulates IgM in lymph nodes 17 of 18 what do th reg do inhibits anitgen presentation-autoimmune 18 of 18
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