Immunology- TCR BCR

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  • Created by: Ruth
  • Created on: 03-02-13 12:39
What are the main structures involved in recognition in the adaptive immune response?
BCR, TCR, MHC class I and MHC class II.
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How does antigen bind to these receptors?
Non covalent bonds.
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What is the structure of the B cell receptor?
Transmembrane antibody. Ascociated with Igalpha and Igbeta chains in the membrane which contain ITAMs.
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What is an ITAM?
Immunoreceptor Tyrosine based Activation Motif.
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What do ITAMs do?
They are phosphorylated by kinases to send signals to the cell nucleus.
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What is the structure of the TCR?
alpha and beta chains or gamma and delta chains. Ascociated with CD3 whichis a combination of two of epsilon delta and gamma chains
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What is the structure of MHC class I?
MHC class I has an active alpha chain and a purely stabilising beta chain. It is present on all cells.
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What type of T cells does MHC class I present to?
CD8+ T cells
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What are CD8+ T cells?
Cytotoxic T cells.
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What is the structure of MHC class II?
Alpha and beta chain are both involved in presentation of antigen.
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Where is MHC class II present?
Professional antigen presenting cells.
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How long are the antigens (in amino acids) presented on MHC class II?
On MHC class II the antigens presented are in lengths of 10-15 amino acids long. On MHC class I they are 8-10 amino acids long.
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Which MHC uses the exogenous pathway to present antigen?
MHC class two. This involves combination of the endosome containing antigen and the endosome containing the MHC molecule combining in the cell.
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What is the endogenous pathway of presenting antigen?
The TAP transports peptides in the ER where they are combined with MHC class I and then presented on the cell surface. This is usually in virus infected cells
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Other cards in this set

Card 2

Front

How does antigen bind to these receptors?

Back

Non covalent bonds.

Card 3

Front

What is the structure of the B cell receptor?

Back

Preview of the front of card 3

Card 4

Front

What is an ITAM?

Back

Preview of the front of card 4

Card 5

Front

What do ITAMs do?

Back

Preview of the front of card 5
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