Immunology Vocabulary 3

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  • Created by: John
  • Created on: 16-03-13 12:38
alleles
Two or more alternative forms of a gene.
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allogeneic
Genetically different individuals of the same species.
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amphipathic
Having both hydrophilic and hyphophobic regions. All proteins which are membrane bound must be amphipathic to be anchored in the lipid bilayer and to be functional in an aqueous environment.
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CD antigens
Cluster designation antigens. The list grows rapidly, as more markers are found and defined.
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class I
MHC encoded antigen consisting of one peptide, which closely associates with beta-2-microglobulin. These antigens are involved in CTL responses.
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class II
MHC encoded antigen consisting of two nonidentical peptides, which are not covalently bound but remain in close association. These antigens are involved in T-helper cell responses.
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congenic
A line of mice that are genetically identical except for a difference in one locus of the major histocompatibility complex.
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gene complex
A cluster of related genes occupying a restricted area of a chromosome.
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genetic restriction
The requirement that interacting cells must have identical MHC haplotypes in order to obtain maximum cooperation.
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H-2
The mouse MHC
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haplotype
The complete set of alleles at all loci within a gene complex on a single chromosome.
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histocompatibility antigens
Cell membrane proteins that provoke an immune response when a tissue is grafted into an allogeneic recipient.
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HLA
Human leukocyte antigen. The human MHC.
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Ia
Mouse class II antigen.
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linkage
The close association of two or more genes on a single chromosome, with the result that they are usually inherited together.
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linkage disequilibrium
An unexpected association of linked genes in a population.
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locus
The location of alleles on chromosomes. In the case of histocompatibility antigens, as many as 30 different alleles can be coded for at one locus, but in any individual animal a single locus can contain only one gene. Because chromosomes are paired,
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major histocompatibility complex (MHC)
A genetic region which is responsible for rapid rejection of grafts between individuals; codes for membrane bound proteins which function in signaling between lymphocytes and APCs.
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polymorphism
Inherited structural differences between proteins from allogeneic individuals. A form of allotypic variation.
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private antigen
An epitope that is restricted to the product of a specific allele.
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public antigen
An epitope common to several distinct gene products.
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T cell receptor (TcR)
A complex of two peptides which function to recognize antigenic determinants and to initiate a response. In TcR2, two peptides, alpha and beta, are linked by one disulfide bond and function much like an immunoglobulin in binding antigen; in fact, the
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Thy-1
An antigen expressed by all T-cells; expressed by brain cells and some epithelial cells as well.
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Other cards in this set

Card 2

Front

Genetically different individuals of the same species.

Back

allogeneic

Card 3

Front

Having both hydrophilic and hyphophobic regions. All proteins which are membrane bound must be amphipathic to be anchored in the lipid bilayer and to be functional in an aqueous environment.

Back

Preview of the back of card 3

Card 4

Front

Cluster designation antigens. The list grows rapidly, as more markers are found and defined.

Back

Preview of the back of card 4

Card 5

Front

MHC encoded antigen consisting of one peptide, which closely associates with beta-2-microglobulin. These antigens are involved in CTL responses.

Back

Preview of the back of card 5
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