Basic Neuroanatomy
(cont.)
D212Z5: Introduction to Animal Physiology Dr John Harris (Feb '13)…read more

General Objectives
· Further introduce basic anatomical and
functional information about the nervous
system
· Build on elements from `Whole Organism
Biology' and `Genetics and Cell Biology'
lectures
· Learn some nervous system terminology
· From neurones (single cell)...
...to nervous system…read more

Overview (1st bit)
· Cytoskeleton
­ Filament types
­ Some functions
­ Axonal transport
· Neuroglia
­ Types
­ Some functions
­ Formation of Blood Brain Barrier
­ Myelination
· Neuronal classification…read more

Cytoskeleton
Network of filamentous structures (not static)
­ cell structure/shape
·Microfilaments.
·Neurofilaments.
(Intermediate
filaments)
· Microtubules.
Present in all cells but complex structure of
neurones means certain specialities..…read more

Are not static ­ have changes in
their structure at various times.
They can move positions to form
new contacts
· Microfilaments located on the inner
edge of the cell.
· Neurofilaments are located in other
parts of the cell too.
· Microtubules located throughout…read more

Microfilaments
· Diameter = 3.7nm. .
· Mostly polymer of globular protein, actin (G-actin)
· Strands intertwine to form filaments (F-actin)
· Prevalent at the edge of the cell
· Roles include:
Support - basic strength and shape of cells; pre- and
post-synaptic specialisations; microvilli
Movement- Growth cone motility; dendritic movements
(remodelling) learning and memory…read more