Produced in somatotroph cellls of the ant.pit. Single chain polypeptide. Half-life 20 mins. Promotes bone growth. Pulsatile
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Transgene
A gene which is artificially introduced into the genome of another organism
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GH Receptor
Single chain glycoprotein, single membrane-spanning domain. Dimerization of 2 receptors, activates intracellular tryosine kinase cascade.
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Laron Syndrom
Body id unable to use growth hormone. Serum GH levels are higher than normal. Caused by non-functioning GH receptors.
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Hypopituitaryism
Too little GH secretion in childhood - dwarfism
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GH-Secreting Pituitary Tumor
GH excess leading to giantism in children and acromegaly in adults.
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Acromegaly
Too much GH produced by the pituitary. Leads to coursening of features but no height gain. Treatment: surgery of tumour removal, radiotherapy, somatostatin analogue, dopamine agonsit.
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Growth Hormone Deficiency
Pituitary gland does not make enough GH.Leads to a shortered height, central obesity, raised lipids in the blood and reduced muscle strength.
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Other cards in this set
Card 2
Front
A gene which is artificially introduced into the genome of another organism
Back
Transgene
Card 3
Front
Single chain glycoprotein, single membrane-spanning domain. Dimerization of 2 receptors, activates intracellular tryosine kinase cascade.
Back
Card 4
Front
Body id unable to use growth hormone. Serum GH levels are higher than normal. Caused by non-functioning GH receptors.
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