Chemistry Unit 1, module 2

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  • Created by: Tina
  • Created on: 04-02-14 11:28
What is a zwitterion?
A dipolar ionic form of an amino acid formed from the donation of H+ ion from carboxyl to amino acid. No overall charge.
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Isoelectric point
pH value at which the amino acid exhists as a zwitterion.
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Condensation reactions
Elimination of water
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Acid hydrolysis of polypeptides and proteins: reagents and conditions
6moldm-3 HCl, 25hrs, reflux
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Alkaline hydrolysis of polypeptides and proteins: reagents and conditions
NaOH, 100'C
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Chiral carbon
A carbon atom attached to 4 different atoms/ groups of atoms.
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Hydrolysis of polyesters and polyamides: 1) acid 2) base
1) NaOH/ H20 /hot 2) H+ / H2O
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Define: pharmaceutical activity
The beneficial or adverse effects of a drug on living matter
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What happens when a drug is made in a lab compared to from a living system?
Lab: mixture of 2 optical isomers formed.
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Advantages of using a singer optical isomer in drugs compared to a number of them?
1) risks from undesirable side effects reduced. 2) drug doses reduced.
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Methods of making a single chiral isomer...
1) Use enzymes as biological cataylsts 2) Chiral pool synthesis 3) use of transition element complexes.
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Other cards in this set

Card 2

Front

Isoelectric point

Back

pH value at which the amino acid exhists as a zwitterion.

Card 3

Front

Condensation reactions

Back

Preview of the front of card 3

Card 4

Front

Acid hydrolysis of polypeptides and proteins: reagents and conditions

Back

Preview of the front of card 4

Card 5

Front

Alkaline hydrolysis of polypeptides and proteins: reagents and conditions

Back

Preview of the front of card 5
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