What are the four main classes of cell adhesion molecules?
Homophilic interactions-cadherins and immunoglobulin superfamily, Heterophilic interactions-Integrins and selectins
2 of 24
What do cadherins bind with?
Calcium binding, so lack of calcium can cause cadherins malfunctions.
3 of 24
What are integrins made of?
alpha and beta chain.
4 of 24
What are selectins made of?
lectins bound to sugars.
5 of 24
What are the types of cellular junction?
Tight junction, Adherens junctions, Gap junction, Desmosome
6 of 24
Where are tight junctions found?
Found in epithelial sheets, helps to form an impermeable barrier, seals gaps between cells, membranes are firmly pressed together.
7 of 24
What do tight junctions do?
It seals off body cavities and restricts diffusion of membrane components.
8 of 24
What are gap junctions?
Is a homophilic interaction.Forms a connexon hemichannel.They are a series of pores connecting adjoining cells and forming a cytoplasmic bridge.
9 of 24
What do gap junctions provide?
chemical and electrical coupling between adjacent cells, permits movement of ions and small molecules.
10 of 24
What do gap junctions allow?
co-ordination of activities in a sheet of cells, allows rapid transmission of nerve impulses.Important for intercellular signaling.
11 of 24
What do adheren junctions do?
Connect the contractile bundles of actin and myosin filaments that run parallel to the plasma membrane.
12 of 24
What do adheren junctions allow?
contraction of epithelial layers. Plays a role in the formation of epithelial tubes
13 of 24
What is loss of adherin associated with?
the metastasis in cancer.
14 of 24
What is a desmosome?
Button like contact points that rivet cells together. Connect intermediate filament networks of adjacent cells.Anchor cells cytoskeleton to plasma membrane and connect the cytoskeleton of surrounding cells giving strength.
15 of 24
What do hemidesmosomes do?
anchor the cell to the basal lamina.
16 of 24
What do integrin containing junctions do?
connect cells to substratum.
17 of 24
What is laminin and fibronectin?
are multiadhesive proteins that bind to components of the extracellular matrix. Laminin is made of 3 different chains which allows it to bind to different cell types.
18 of 24
What is the basal lamina?
Specialized region of extracellular matrix that provides a solid substratum for epithelial cells to connect to. There are different basal lamina structures for different tissues.
19 of 24
What is the extracellular matrix?
Fibrous network of proteins and polysaccharides that fills the spaces between cells.
20 of 24
What does the extracellular matrix do?
holds cells and tissues together.Plays a role in embryogenesis, wound healing, and cell migration.
21 of 24
How thick is the basal lamina?
40-120nm thick
22 of 24
What does the basal lamina surround?
individual muscle cells, fat cells and Schwann cells also underlies all epithelia.
23 of 24
What is the basal lamina made of?
laminin,type IV collagen-gives the basal lamina tensile strength, nidogen, Perlecan,collagen XVIII, Fibronectin
24 of 24
Other cards in this set
Card 2
Front
What are the four main classes of cell adhesion molecules?
Back
Homophilic interactions-cadherins and immunoglobulin superfamily, Heterophilic interactions-Integrins and selectins
Comments
No comments have yet been made