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1. What does the tumour supressor gene do?

  • They code for proteins that control cell cycle progression/proliferation (many of which are check point genes.
  • The proteins can't initiate apoptosis if DNA damage is irreparable
  • e.g.P35 gene encoded by the TP53 gene on the short arm of chromosome 17 and regulates cell cycle
  • They code for signalling proteins that codes signalling molecules e.g growth factors, protein kinase and transcription factor
  • Can't induce growth arrest at G1/S regulation point (restriction point)
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2. BCR ABL kinases don't

  • initiate abnormal signalling pathways
  • Initiate denaturing of checkpoint proteins
  • initiate deregulation of signalling network
  • transcriptional deregulation of cell

3. How is proliferation controlled in normal cells

  • Activate oncogenes transiently (i.e for a short by mitogens) and INactivate tumour suppressor genes transeintly
  • Uncontroled activation of oncogenes and deactivation of tumour supressor genes

4. Which of these is correct for a normal cell?

  • balance process disrupted
  • By reducing the immune barrier
  • balance between the growth promoting and restriction factors
  • Loss of differentiation
  • Continue cell proliferation
  • Apoptosis doesn't occur

5. Which of these is incorrect about Philiadelphia chromosome?

  • occurs between chromosomes 9 and 21 by reciprocal translocation
  • BCR - ABL fusion gene encodes BCR ABL kinases -which is unique to Lukemia cells


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