Cancer

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1. How is proliferation controlled in normal cells

  • Activate oncogenes transiently (i.e for a short by mitogens) and INactivate tumour suppressor genes transeintly
  • Uncontroled activation of oncogenes and deactivation of tumour supressor genes
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2. Which of these is incorrect about Philiadelphia chromosome?

  • occurs between chromosomes 9 and 21 by reciprocal translocation
  • BCR - ABL fusion gene encodes BCR ABL kinases -which is unique to Lukemia cells

3. BCR ABL kinases don't

  • Initiate denaturing of checkpoint proteins
  • transcriptional deregulation of cell
  • initiate deregulation of signalling network
  • initiate abnormal signalling pathways

4. How can Mitotic crossover play a role in cancer?

  • It is an event where a cancer causing reccesive allele may be expressed and thus predispose the cell causing development of cancer
  • It does not play a role
  • It is an event where a cancer causing dominant allele is sometimes expressed and thus predispose the cell causing development of cancer

5. Which of these is correct for a normal cell?

  • balance process disrupted
  • balance between the growth promoting and restriction factors
  • Apoptosis doesn't occur
  • Loss of differentiation
  • Continue cell proliferation
  • By reducing the immune barrier

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