Blood - Platelets and Heamostasis

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U L E B T H R O M B O P O I E T I N E U E
R N L X L L J E X P P B H N P B E D L W C
E P H N B Y B T N I T R I C O X I D E W Y
A D E N O S I N E D I P H O S P H A T E R
F Y E S K X K A U T C U D T B J K J Q P X
M E G A K A R Y O C Y T E S K G O J H I H
Y M P B W I F N B C O A G U L A T I O N K
L A G F I B R I N T H R E A T S C J B O C
L R K V V C A O E H R V C N T F G C D W Q
T S I E T D A H A E M O S T A S I S U N X
C J H P M Q S Q Q G Y R L D D J Q M D F R
C V F Y U E M Y D L I G L P X L M Q C B K
K T T O I E O A S Q U T L C P C B H Y A R
R R E D M A R R O W S I N U S O I D H C S
G E R F U U U V T L G S U Q B V L F Q D O
O C T F H M N P D V K U U H H L X K X C M
V O N W I L L E B R A N D F A C T O R U J
O F Y N H I M Y L Q Y C K W E L X B I K B
D N V E C Y T O K I N E S I S J B Q I Y F
Y V V B O E B S A R P G D E R X L B O S C
I V U K D I I A D Y P R W L J G P B R K H

Clues

  • Coagulation reinforces platelet plug with __________ that act as glue (6, 7)
  • Platelets are cytoplasmic fragments of larger cells called _________ (14)
  • Platlets are kept mobile but inactive by ________ and prostacyclin, which are secreted by endothelial cells lining the blood vessels (6, 5)
  • The mature megakaryoblast presses against a sinusoid in the _________ and sends cytoplasmic extensions through the _______ wall, which rupture and release platelets into the bloodstream (3, 6, 8)
  • The megakaryoblast repeatedly mitoses but _________ does not occure, resulting in a stage IV megakaryocyte (11)
  • The series of reactions set in motion to stop bleeding after a blood vessel wall breaks (11)
  • There are essentially three steps to haemostasis: vascular spasm, platelet plug formation and ___________ (11)
  • What hormone regulates the formation of platelets? (14)
  • When platelets adhere to collagen, they release chemical messengers including: _______, serotonin and thromboxane A2 (9, 11)
  • Which plasma protein stabilises bound platelets and collagen fibers? (3, 10, 6)

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