Sickle-cell anaemia is caused by a faulty recessive allele that codes for Haemoglobin. Some of the red blood cells go out of shape causing these symptoms:
- severe pain, when sickled red blood cells block tiny blood vessels.
- anaemia as damaged cells cant be replaced fast enough.
- tiredness cause by a shortage of oxygen.
However people who carry just one sickle-cell allele are less likely to get malaria. They have an improved chance of survival. So, the frequency of the sickle-cell allele has increased in places where malaria is a problem This is an example of natural selection.
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